acylcarnitines, TMAO, cholines, betaines, SAM, SAH, nucleotides and nucleosides, methylated and acetylated amines, di- and oligopeptides
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- For blood plasma, cells, and tissue samples of various origins, normalized relative intensities are reported for up to 300 identified biogenic amines in addition to a large list of unknowns. Biogenic amines are identified by matching mass spectra in a targeted library of MS/MS spectra in addition to accurate masses and retention time matching.
- Untargeted data processing may add a large number of additional metabolites of unknown chemical structure.
- Samples from other sources (tissues, urine, cell cultures) may differ in the number of identified and unidentified compounds.
- All biogenic amines are reported by retention times, quantification masses, biochemical database identifiers and adduct information. Biogenic amines are quantified by peak heights, not in absolute concentrations. However, we are adding 9 internal standards to convert peak heights into good estimates of absolute (micromolar) concentrations for a range of biogenic amines typically detected in biofluids and tissues! Through untargeted analyses, we also detect exposome-type compounds, from microbial conversions of food metabolites to pharmaceutical drugs.