Pilot and Feasibility Projects
West Coast Metabolomics Center - Pilot and Feasibility Projects
One goal of the West Coast Metabolomics Center is to rapidly advance metabolomics research by providing funds to support novel projects and challenging ideas proposed by scientists throughout the United States, in particular along the West Coast.
Funded Projects 2013
After a thorough three-tiered review and decision process, we congratulate the following applicants to receive funding for their pilot grant application with the West Coast Metabolomics Center at UC Davis.
Graeme Bell, University of Chicago with collaborator Manami Hara and the WCMC laboratories Fiehn, Hammock and the WCMC central service core.
"Combined Metabolomics and Lipidomics of Type 1 Diabetes"
Michele La Merrill, UC Davis, and the WCMC laboratories Gaikwad, Hammock, Newman and the WCMC central service core.
"Dysfunctional Lipid Metabolism Underlies the Effect of Perinatal DDT Exposure on the Development of Metabolic Syndrome "
Ernst Lengyel, University of Chicago with WCMC laboratories Newman and Fiehn
"A Study of Changes in Lipid Metabolism of Ovarian Cancer Cells Co-Cultured with Adipocytes"
Peter Kaiser, UC Irvine, and the Fiehn WCMC laboratory
"Metabolite Changes Associated with Methionine Stress Sensitivity of Cancer"
Roel Ophoff, UC Los Angeles with collaborator Steve Horwath and the WCMC laboratories Fiehn, NMR service core and the WCMC service core.
"Biomarkers for Depression in CSF and Plasma in a Population Sample"
Pei-an Shih, UC San Diego with collaborator Walter Kaye and the Hammock WCMC laboratory
"Quantitative Profiling of Eicosanoids to Explore Molecular Mechanisms Underlying Anorexia Nervosa"
Patricia Thompson, University of Arizona with the Hammock WCMC laboratory
"Application of Oxylipin Metabolomics to a Celecoxib Intervention in Men at Risk for Colorectal Neoplasia Recurrence"
Johanna Lampe, Fred Hutchinson Cancer Research Center at Univ. of Washington, Seattle with the WCMC Fiehn lab and the metabolomics service core.
"Metabolic Profiling of Visceral and Subcutaneous Adipose Tissue from Colorectal Cancer Patients: Unraveling the Link Between Adipose Tissue and Cancer"
Rudy Ortiz, UC Merced with the WCMC laboratories Newman, Fiehn, and the WCMC bioinformatics and metabolomics service cores.
"Metabolomic and Lipidomic Profiles in Response to Exogenous Insulin and GLP-1 Infusions during Prolonged Fasting"
Patricia Oteiza, UC Davis in collaboration with with the WCMC Gaikwad laboratory
"Disruption of Zinc Homeostasis can Impair Maternal Glucocorticoid Metabolism: Consequences on the Developing Fetus"
Vivian Hook, UC San Diego with the WCMC Fiehn laboratory and the WCMC metabolomics service core.
"Metabolomics Analyses of Neurotransmitter Profiles Regulated in Schizophrenia Modeled in Human Induced Pluripotent Stem Cells"
Jayoung Kim, Cedars-Sinai Medical Center, Los Angeles with the WCMC Fiehn laboratory and the WCMC metabolomics service core.
"Urinary Metabolites in IC/PBS Diagnosis"
We look forward to these exciting projects!
All award recipients will participate at our annual retreat with presentations as well as in in workshops and mentoring of trainees. For all presentations and publications, P&F funding by the NIH West Coast Metabolomics Center must be cited. Center staff will monitor project deliverables.
We will use very similar criteria and details as we had for the past round of pilot projects. Please, start working with the WCMC on your metabolic aims and service budgets for your 2013/2014 early in the process to avoid being triaged for non-compliance reasons.
The following criteria and details are important to note for .
Download the submission template here.
- Submissions for maximum of $50,000 in metabolomic services.
- One year maximum funding period
- No salary support for investigator or investigator staff is permitted
- Consult with WCMC advanced laboratories about budget estimates.
- Budget for WCMC advanced service laboratory staff will go in increments of 1-person months plus consumables needed to perform the project.
FAQ on writing the budget part of the application:
How does the funding actually work? Would it come through the applicant's institution?
No. Please, think about writing the budget section more like a 'voucher system'. There will be no actual money transfer out of UC Davis. Again, no salary support for investigator staff is permitted (including tuition fees or other salary parts). Rather, if successful, services rendered by the WCMC will be allocated to the different WCMC labs internally, i.e. paying for staff and consumables here in Davis to fulfill our part of the metabolomics collaboration. Please contact your partner labs (i.e. the Advanced Service labs Hammock, Newman, Cherry, Lebrilla, Fiehn, Gaikwad, Weimer) for estimates how long they would need to work on the aims you will propose, and if there would be additional consumables needed. As stated above, the time intervals would go in 1-person-month increments, roughly worth $5,000 each. However, if needed for the aims, one could also use other core services at UC Davis, e.g. the NMR core, the bioinformatics core or even the metabolomics mass spec core (see Core Services for costs and contact managers). Even portions from other UC Davis cores would be allowable, e.g. the Mouse Metabolic Phenotyping Center, or the genomics or proteomics service cores at the UC Davis Genome Center.
In addition, you can ask for reasonable costs for travel to UC Davis to participate in WCMC events (symposia, workshops, courses, and collaborative meetings with your partner labs). Such costs would be reimbursed based on economy trips directly by the WCMC.
Investigator must be eligible for as PI for NIH grants
- Young investigators and investigators who are new to the field of metabolomics are especially encouraged to apply
- Investigator can be located anywhere in the United States, but can only submit P&F application to one (1) NIH metabolomics resource core per year
- At least half of all projects will be funded for investigators located outside of UC Davis
- Length of proposal 5-pages (Background, Hypothesis, Plan, Justification of Resources)
- Application should include plans for new extramural grant submissions
- Application assistance / Q&A through workshop with video recording and call-in phone number, January 2014
- Submission due date March 01, 2014
- Earliest project start date May 01, 2014
- Reviews will follow the NIH format criteria (Significance, Investigators, Innovation, Approach, Environment), using the NIH scoring system
- Final decisions will be made by an external NIH / executive committee
The West Coast Metabolomics Center specifically encourages applications that foster collaborations, for example by applications that
- span scientific domains and metabolic platforms - for example by collaborating with more than one WCMC advanced services laboratory.
- fulfill needs that benefit multiple investigators
- detail the collaborative aspect with the Center, e.g. partner with one or more of the Advanced Service laboratories
- include a mentoring and trainee plan
- participate in Center events such as the annual retreat, seminars and courses. For such events, modest travel funds can be requested.
UC Davis Genome Center Pilot and Feasibility Projects
The Genome Center is soliciting applications for up to five small metabolomic pilot grants per year for up to $2,000 per project. Such grants are available for Principal Investigators located at UC Davis, but outside regional scientists are not eligible. In a similar manner like the West Coast Metabolomics Center pilot projects, the intent of such startup grants is to obtain data for NIH grant submissions. Project submissions can be sent any time to email@example.com; reviews will be scored by NIH criteria (significance, investigator, innovation, approach, environment). Leveraging with other funding mechanisms, including other Genome Center core pilot grants, is most welcome.
For more information, contact firstname.lastname@example.org