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Imaging

Center for Molecular and Genomic Imaging

opticalmrictspect-imagepet-imageultrasound

For more sample images please visit the Imaging Center's image gallery

 

The Center for Molecular and Genomic Imaging is a fully equipped small animal imaging facility that provides PET, SPECT, CT, MRI, optical, ultrasound and autoradiographic imaging services to researchers in academic institutions and in private industry. In addition, a biomedical cyclotron and radiochemistry laboratory allow on-site synthesis of custom radiotracers.

Areas of active research include the development of new and improved imaging technologies, the design of novel contrast agents and imaging probes and their application in molecular diagnostics and therapeutics.

We foresee activities as part of the Metabolomics Core Services developing in three directions:

First, many imaging techniques, for example using metabolic tracers such as 18F-fluorodeoxyglucose, directly inform researchers about the location of metabolic alterations. This information will lead to better guidance for subsequent tissue biopsies. Many users of the imaging facility are particularly interested in the site ofaction and accumulation of drugs that are imaged, for example, using fluorescent tracer molecules.

The imaging facility also plans to develop ‘image-guided metabolomics services.’Using a Barlow imaging cryomicrotome, users of the imaging facility can combine the use of their fluorescent agents with fluorescence-guided microtome dissection into tissue slices which then can be either used directly for metabolomic extractions and analysis, or will be used in conjunction with laser capture microdissection technology.

Lastly, we will extend these services toward mass spectrometry imaging. We do not foresee image-guided metabolomic services and mass spectrometry-based imaging to be available for fee-for-services immediately, but we intend to open metabolomic imaging through Pilot and Feasibility studies beginning in year 1 (2012/2013 budget year).

Services and Rates

Unassisted Imaging Rates

ServiceUniversity of California Rate Educational/Non-Profit Off-Campus/Corporate Rate
PET/SPECT/CT

$102/Hour

$165/Hour

$204/Hour

Optical

$46/Hour

$75/Hour

$93/Hour

MRI

$102/Hour

$165/Hour

$204/Hour

Specialty equipment 1

$26/Hour

$43/Hour

$53/Hour

Assisted Imaging Rates2

ServiceUniversity of California Rate Educational/Non-Profit Off-Campus/Corporate Rate
Labor (data aquisition/analysis)

$136/Hour

$220/Hour

$272/Hour

PET/SPECT/CT

$236/Hour

$220/Hour

$272/Hour

Optical

$182/Hour

$295/Hour

$365/Hour

MRI

$238/Hour

$385/Hour

$476/Hour

Specialty equipment 1

$162/Hour

$263/Hour

$325/Hour

After Hours Imaging Rates3

ServiceUniversity of California Rate Educational/Non-Profit Off-Campus/Corporate Rate
PET/SPECT/CT

$84/Hour

N/A

N/A

Optical

$36/Hour

N/A

N/A

MRI

$84/Hour

N/A

N/A

Specialty equipment 1

$20/Hour

N/A

N/A

Radiochemistry Rates

ServiceUniversity of California Rate Educational/Non-Profit Off-Campus/Corporate Rate
[18F]FDG (up to 2 mCi) 4

$60/dose

$97/dose

$120/dose

18F- and 11C-PET Tracers 5

$1,199

$1,934

$2,383

Cyclotron-produced 18F
(up to 3500 mCi) 6

$999

$1,612

$1,986

Cyclotron-produced 64Cu
(150 – 200 mCi) 6

$1,999

$3,224

$3,972

Radiochemistry Labor

$136/hr

$220/hr

$272/hr

64Cu-, 89Zr-, and 124I- PET Tracers

$26/Hour

$43/Hour

$53/Hour

99mTc-, 111In-, and 123I- SPECT Tracers

$26/Hour

$43/Hour

$53/Hour

1 Specialty equipment includes a cryostat, phosphor imager and a gamma counter.

2Assisted rate is the sum of the specific scanner rate and labor rate, and assumes one staff member is needed.

Very complex studies may require an additional staff member and an additional labor charge.

3 Unassisted imaging by trained UCD personnel on weekdays (7 pm to 7 am), weekends and holidays.

4 [18F]FDG is obtained from a third party supplier and prices are subject to change.

Quantity discounts are available; for example, 3-15 mCi is $150 (UC), $242 (non-UC academic), and $298 (private industry).

518F- and 11C-PET tracers in routine production, and typical quantities produced, are:

[18F]FLT, [18F]FHBG, and [18F]FMISO (each 100 mCi);

[18F]FBA and [18F]SFB (for peptide labeling; 1500 mCi);

[11C]Raclopride, [11C]SCH23390, and [11C]PK11195 (each 15 mCi).

For structural information and applications of these tracers, click here.

Custom syntheses: please inquire.

6 Use of the radiochemistry laboratory for one day is included with cyclotron-produced 18F and 64Cu.

Equipment

The center provides the following imaging modalities:

  • Autoradiography
  • X-Ray Computed Tomography (CT)
  • Magnetic Resonance Imaging (MRI)
  • Optical Imaging (Fluorescence and Bioluminescence)
  • Positron Emission Tomography (PET)
  • Single Photon Emission Computed Tomography (SPECT)
  • Ultrasound

Staff

Dr. Douglas Rowland, Scientific Manager

David Kukis, Manager, Cyclotron and Radiochemistry Facility

Dr. Simon Cherry, Director

Dr. Julie Sutcliffe, Co-Director

 

 

Contact:

Email: cmgiimaging@ucdavis.edu.

Phone:  (530) 754-8960

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